Histamine food poisoning is caused by ingestion of large amounts of histamine accumulated in food. Histamine is produced from histidine by histidine decarboxylase in histamine-producing bacteria. Therefore, histamine food poisoning is common
in red meat fish (tuna, bonito, mackerel, sardine, saury, etc.) with high free histidine content. Symptoms of histamine food poisoning are allergy-like symptoms such as urticaria and nausea, and it has been called allergy-like food poisoning in Japan.
Since histamine is heat-stable, once histamine accumulates, food poisoning may occur even in foods that have been cooked.
