Quantification of IGF-binding proteins is useful
セクションアウトライン
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IGFBP regulates the growth-promoting effect of IGF-I. Three main types are found in the blood of Salmonids, namely, IGFBP-2b, -1a, and -1b in descending order of molecular weight. These are important in terms of their ability to regulate IGF-I activity. However, we believe that these are also useful as growth indicators in terms of reflecting growth status. As shown in the figure below, differences in the IGFBP patterns in the blood can be observed when juvenile Chinook salmon (Oncorhynchus tshawytscha) are reared separately in a feeding group and fasting group. For example, the amount of IGFBP-2b is high in the feeding group, whereas IGFBP-1b is high in the fasting group. Using these IGFBPs together with IGF-I as the positive and negative indicators of growth enables the possibility of more accurately evaluating the growth rate of salmon. This is expected to improve the efficiency of the aquaculture industry and hatchery release program.
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